Polluted Pathways: Mechanisms of Metabolic Disruption by Endocrine Disrupting Chemicals
نویسندگان
چکیده
منابع مشابه
Chemical Genomic Study of Endocrine Disrupting Chemicals in Metabolic Pathways
Endocrine disrupting activities in industrial chemicals have been a serious problem, because they are distributed broadly, they are active at very low concentrations, and some of them are difficult to detoxify. Moreover, only a small number of active chemicals are known, while most chemicals have not been examined yet. To reduce the number of examinations required for unknown chemicals, some co...
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The global epidemic of metabolic disease is a clear and present danger to both individual and societal health. Understanding the myriad factors contributing to obesity and diabetes is essential for curbing their decades-long expansion. Emerging data implicate environmental endocrine disrupting chemicals (EDCs) in the pathogenesis of metabolic diseases such as obesity and diabetes. The phenylsul...
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The idea that xenobiotic chemicals could inappropriately modlate the endocrine system thereby causing detrimental effects n wildlife and humans was first proposed 20 years ago at the atershed Wingspread Conference [1,2]. These endocrine disruptng chemicals (EDCs) have long been controversial, with a great eal of discussion raging in the scientific literature. Much of this ontroversy has centere...
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Communication on a cellular level--defined as chemical signaling, sensing, and response--is an essential and universal component of all living organisms and the framework that unites all ecosystems. Evolutionarily conserved signaling "webs," existing both within an organism and between organisms, rely on efficient and accurate interpretation of chemical signals by receptors. Therefore, endocrin...
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Rapid regulatory developments in the area of environmental endocrine disruption present a series of potential problems that are identified and illustrated with examples taken from the recent literature. A list of priorities is provided, including the need for additional epidemiological and wildlife studies, the derivation of a coordinated testing strategy, agreement on the toxicities expected o...
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ژورنال
عنوان ژورنال: Current Environmental Health Reports
سال: 2017
ISSN: 2196-5412
DOI: 10.1007/s40572-017-0137-0